Table 1
Clinical characteristics of septic patients and healthy controls
| Parameter | Healthy controls (n=22) |
All patients (n=96) |
Survivors (n=75) |
Non-survivors (n=21) |
P-value |
|---|---|---|---|---|---|
| Age (years) a | 50(46-65) | 55(47-78) | 53(47-65) | 63 (57-78) | 0.13 |
| Sex (M/F) a | 16/6 | 65/31 | 50/25 | 15/6 | 0.800 |
| WBC /(109/L) b | 6.0±0.34 | 16.3±1.13 | 15.9±1.07 | 20.5±3.48 | 0.220 |
| RBC /(109/L) b | 135.3±1.66 | 101±1.88 | 106.7±2.09 | 95.3±4.03 | 0.013 |
| PLT /(109/L) b | 218.8±14.82 | 87.0±3.29 | 107.1±1.72 | 55.4±5.64 | <0.001 |
| PCT /(ng/mL) b | 0.03±0.002 | 35.3±2.74 | 18.9±1.13 | 62 ±7.71 | <0.001 |
| CRP /(ng/mL) b | 0.6±0.04 | 161.7±6.02 | 147.4±8.65 | 207.2±14.72 | 0.007 |
| ALB /(g/L) b | 41±0.81 | 24.8±0.40 | 25.8±0.35 | 21.9±1.14 | 0.020 |
| Scr b | 75±2.62 | 146.8±9.24 | 112.2±7.15 | 182.5±28.17 | 0.023 |
| Lactate /(mmol/L) b | 1.2±0.11 | 6.0±0.40 | 4.4±0.37 | 9.7±0.61 | <0.001 |
| PT /s b | 13.1±0.28 | 19.1±0.32 | 17.4±0.25 | 21.1±0.66 | <0.001 |
| Fibrinogen /(g/L) b | 3.0±0.23 | 4.4±0.23 | 5.5±0.18 | 3.4±0.50 | <0.001 |
| SOFA score b | — | 8.5 ± 0.33 | 7.7 ±0.30 | 11.2 ± 0.85 | <0.001 |
| APACHE II score b | — | 14.3±0.43 | 20.1±0.72 | 22.2±1.42 | <0.001 |
| HMGB1 b | 1.0±0.23 | 12.8±0.71 | 10.4±0.69 | 17±1.33 | <0.001 |
| miR-146b b | 0.96±0.13 | 0.8±0.07 | 0.93±0.06 | 0.36±0.07 | <0.001 |
| Time of ICU stay /days b | — | 11.4±0.49 | 12.4±0.44 | 7.7±1.33 | <0.001 |
aData are presented as median (range) or number; bData are expressed as mean ±SEM Abbreviations: WBC: white blood cell; RBC: red blood cell; PLT: platelet; PCT: procalcitonin; CRP: C-reactive protein; ALB: albumin; Scr: serum creatine; PT: prothrombin time; SOFA: sequential organ failure assessment; APACHE II: acute physiology and chronic health evaluation II; HMGB1: high mobility group box-1. P-values were calculated for comparisons between survivors and non-survivors, with significance set at P < 0.05
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