Fig.1
Ligand-Controlled, Nickel-Catalyzed Stereodivergent Construction of 1,3-Nonadjacent Stereocenters
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(a) The difficulty of asymmetric induction. (b) Kong and his collaborators successfully achieved the stereodivergent construction of oxindoles containing 1,3-nonadjacent stereocenters. (c) Four stereoisomers were prepared from the same substrate using four different chiral ligands. (d) Mechanistic study with or without MgCl2. (e) DFT calculations for the origin of diastereoselectivity in the presence of MgCl2 (1 kcal = 4.18 kJ)
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