Open Access
Issue
Wuhan Univ. J. Nat. Sci.
Volume 31, Number 3, June 2026
Page(s) 250 - 254
DOI https://doi.org/10.1051/wujns/2026313250
Published online 24 June 2026

© Wuhan University 2026

Licence Creative CommonsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

0 Introduction

We consider the following model of a Keller-Segel-Navier-Stokes with subcritical sensitivity[1-2]:

t u + u u + π - Δ u = n ϕ , Mathematical equation(1)

d i v u = 0 , Mathematical equation(2)

t n + u n - Δ n = - ( n S ( x , n , p , q ) p ) - ( n S ( x , n , p , q ) q ) , Mathematical equation(3)

t p + u p - Δ p = - n p , Mathematical equation(4)

t q + u q - Δ q + q = n   i n   Ω × ( 0 , ) , Mathematical equation(5)

u = 0 , n v = p v = q v = 0   o n   Ω × ( 0 , ) , Mathematical equation(6)

( u , n , p , q ) ( , 0 ) = ( u 0 , n 0 , p 0 , q 0 ) ( )   i n   Ω R 2 , Mathematical equation(7)

where uMathematical equation is the velocity of the fluid, πMathematical equation is the pressure, n,pMathematical equation and qMathematical equation denote the density of amoebae, oxygen and chemical attractant, respectively. The smooth function ϕ:=ϕ(x)Mathematical equation is a potential. SMathematical equation is the chemotactic sensitivity. ΩMathematical equation is a bounded convex domain with smooth boundary ΩMathematical equation, vMathematical equation is the unit outward normal vector to ΩMathematical equation.

The two-dimensional Keller-Segel-Navier-Stokes system serves as a fundamental mathematical model for characterizing the dynamic evolution of chemotactic biological populations in fluid environments[3-4]. Its physical foundation stems from bidirectional coupling between chemotactic behavior and fluid motion: biological entities form aggregation patterns through sensing chemical concentration gradients (Keller-Segel mechanism), while viscous fluid flow (Navier-Stokes equations) alters population distribution via turbulent or laminar transport. The subcritical sensitivity condition further regulates biological response intensity to prevent solution blowup. This study establishes the theoretical conditions ensuring global existence of strong solutions for the two-dimensional Keller-Segel-Navier-Stokes system under the subcritical sensitivity condition in bounded domains. Beyond providing a supplementary analytical approach for chemotaxis-fluid systems, the research advances understanding of nonlinear stability mechanisms in biological-fluid interactions through energy estimation methods for coupled systems. Its practical significance lies in offering theoretical support for biomedical and environmental engineering applications, including tumor cell migration modeling, algal bloom prediction, and microfluidic chip design. Methodologically, the developed techniques for a priori estimates and compactness arguments provide transferable mathematical tools for interdisciplinary research in magnetohydrodynamics and other complex systems.

Recent advances in mathematical modeling of chemotaxis-fluid systems have yielded significant insights. Bellomo et al[5] conducted a comprehensive analysis of Keller-Segel models and their modifications, deriving macroscopic formulations through kinetic theory that prevent non-physical solution blow-up. Kiselev and Ryzhik[6] demonstrated that chemotactic interactions can achieve near-complete biological reaction efficiency (>99%), with this enhancement being independent of reaction amplitude, thereby revealing fundamental nonlinear coupling mechanisms. In two-dimensional domains, Wang et al[7] established global weak solution existence for the chemotaxis-Navier-Stokes system under subcritical sensitivity conditions (α>13Mathematical equation), providing methodological foundations for our strong solution analysis. For three-dimensional cases, Fan and Li[8] proved vanishing viscosity limits using LpMathematical equation-energy methods, though their approach did not address stability regulation by subcritical parameters. This study presents a proof of global strong solution existence for two-dimensional systems with subcritical sensitivity (where χMathematical equation denotes the chemotactic sensitivity coefficient and χ* Mathematical equation is the critical threshold, satisfying  χ<χ* Mathematical equation) in bounded domains. Through hierarchical energy estimates and Poincaré inequality control, we reveal the deterministic role of subcritical conditions in maintaining system stability.

When u=0Mathematical equation, system (3), (4) and (5) reduces to the Keller-Segel system[9-11], which received many studies[12-18].

Fan and Zhao[19] established some regularity criteria when q=0Mathematical equation.

We assume that SC2(Ω¯×[0,)3)Mathematical equation has the property that there exist S00Mathematical equation and α>0Mathematical equation fulfilling

| S ( x , n , p , q ) | S 0 ( 1 + n ) - α   f o r   a l l   x Ω ¯ , n 0 , p 0   a n d   q 0 , Mathematical equation(8)

where we evidently may assume without loss of generality that α<12Mathematical equation .

When p=0Mathematical equation, Wang et al[7] showed the global existence of strong solutions.

The aim of this paper is to generalize the results in Ref. [7] to the case p0Mathematical equation, we will prove

Theorem 1   Let u0H01H2,n0,p0,q0H2,Mathematical equation div u0=0,n0,p0,q00,Mathematical equation in ΩMathematical equation and n0v=p0v=q0v=0Mathematical equation on ΩMathematical equation. Suppose that ϕ:=ϕ(x)Mathematical equation is a smooth function and (8) holds true. Then the problem (1)-(7) has a unique strong solution (u,n,p,q)Mathematical equation satisfying

u , n , p , q L ( 0 , T ; H 2 ) L 2 ( 0 , T ; H 3 ) , t u , t n , t p , t q L ( 0 , T ; L 2 ) L 2 ( 0 , T ; H 1 ) Mathematical equation(9)

for any given T>0Mathematical equation.

1 Proof of Theorem 1

This section is devoted to the proof of Theorem 1. It is easy to show the local well-posedness of smooth solutions, we only need to prove some a priori estimates (9).

First, by the maximum principle, and integrating (3) over Ω×(0,t),Mathematical equationwe get

n , p , q 0 , p C ,   a n d   n d x = n 0 d x . Mathematical equation(10)

Integrating (5) over Ω, we see that

d d t q d x + q d x = n d x = n 0 d x , Mathematical equation

which gives

q d x e - t q 0 d x + ( 1 - e - t ) n 0 d x . Mathematical equation(11)

Testing (3) by n2α-1Mathematical equation, using (2) and (8), we find that

- 1 2 α d d t n 2 α d x + 1 - 2 α α 2 | n α | 2 d x = - n S p n 2 α - 1 d x - n S q n 2 α - 1 d x C | n α p | d x + C | n α q | d x          1 8 1 - 2 α α 2 | n α | 2 d x + C 1 | p | 2 d x + C 2 | q | 2 d x . Mathematical equation(12)

Testing (4) by pMathematical equation and using (2) and (10), we deduce that

1 2 d d t p 2 d x + | p | 2 d x + n p 2 d x = 0 , Mathematical equation

which yields

0 T | p | 2 d x d t C . Mathematical equation(13)

Testing (5) by qMathematical equation and using (2), we infer that

1 2 d d t q 2 d x + | q | 2 d x + q 2 d x = n q d x n L θ q L θ θ - 1 C n L θ q H 1 1 2 q H 1 2 + C n L θ 2 .                   Mathematical equation(14)

On the other hand, we first impose the condition that

θ < 1 1 - α . Mathematical equation(15)

Then, by applying Young's inequality under this constraint, we observe that

n L θ 2 = n α L θ α 2 α C ( n α L 1 α 2 α θ n α L 2 2 ( θ - 1 ) α θ + n α L 1 α 2 α )           Mathematical equation

        C n α L 2 2 α ( 1 - 1 θ ) + C 1 8 1 - 2 α α 2 n α L 2 2 + C . Mathematical equation(16)

Summing up (12) and (14), using (13), (16) and the Gronwall inequality, we have

q 2 d x + 0 T ( | n α | 2 + | q | 2 ) d x d t C . Mathematical equation(17)

Using the Gagliardo-Nirenberg inequality and (17), we have

0 T n L r 2 r α r - 1 d t = 0 T n α L r α 2 r r - 1 d t C 0 T n α L 1 α 2 r - 1 n α L 2 2 d t + C 0 T n α L 1 α 2 r r - 1 d t C + C 0 T n α L 2 2 d t C [ f o r ]   [ a l l ] 1 < r < , Mathematical equation(18)

and

0 T n L 1 1 - α 2 d t C . Mathematical equation(19)

Testing (1) by uMathematical equation and using (2) and (19), we have

1 2 d d t | u | 2 d x + | u | 2 d x = n φ u d x φ L n L 1 1 - α u L 1 α Mathematical equation

C n L 1 1 - α u L 2 1 2 u L 2 2 + C n L 1 1 - α 2 , Mathematical equation

which implies

u L ( 0 , T ; L 2 ) + u L 2 ( 0 , T ; H 1 ) C . Mathematical equation(20)

Testing (5) by qr-1(r2)Mathematical equation and using (2), (18) and by the same calculations as those in Ref. [5], we have

q r d x C   f o r   a l l   2 r < . Mathematical equation(21)

We omit the details here.

Testing (3) by ln nMathematical equation, using (2), and by the same calculations as that in Ref. [5], we have

( p , q ) L ( 0 , T ; H 1 ) + ( p , q ) L 2 ( 0 , T ; H 2 ) C , Mathematical equation(22)

n L 2 ( 0 , T ; L 2 ) + n L 2 ( 0 , T ; L 2 ) C , Mathematical equation(23)

and hence we omit the details here.

Using (23), testing (1) by π-ΔuMathematical equation we easily get

u L ( 0 , T ; H 1 ) + u L 2 ( 0 , T ; H 2 ) + t u L 2 ( 0 , T ; L 2 ) C . Mathematical equation(24)

Testing (3) by n-1(2)Mathematical equation, using (2) and (22), we have

1 d d t n d x + 4 ( - 1 ) 2 | n 2 | 2 d x = n S ( p + q ) n - 1 d x C | ( p + q ) | n 2 | n 2 | d x C ( p + q ) L 4 n 2 L 4 n 2 L 2 C ( p + q ) L 4 ( n 2 L 2 1 2 n 2 L 2 1 2 + n 2 L 2 ) n 2 L 2              - 1 2 n 2 L 2 2 + C ( ( p + q ) L 4 4 + 1 ) n 2 L 2 2 ,                     Mathematical equation

which gives

n d x + 0 T | n | 2 d x d t C   f o r   a l l   2 < . Mathematical equation(25)

By the standard LMathematical equation-estimate of heat equations, it follows from (5), (25) and (24) that

q L ( 0 , T ; L ) C . Mathematical equation(26)

It follows from (4), (5), (22) and (24) that

( t p , t q ) L 2 ( 0 , T ; L 2 ) C . Mathematical equation(27)

Applying tMathematical equation to (1), testing by tuMathematical equation, using (2), (3), (24), (25) and (22), we have

1 2 d d t | t u | 2 d x + | t u | 2 d x = - t u u t u d x + t n φ t u d x = - t u u t u d x Mathematical equation

+ ( Δ n - d i v ( u n + n S p + n S q ) ) φ t u d x Mathematical equation

= - t u u t u d x + ( - n + u n + n S ( p + q ) ) ( φ t u ) d x Mathematical equation

u L 2 t u L 4 2 + C ( n L 2 + u L 4 n L 4     + n L 4 ( p + q ) L 4 ) t u L 2 Mathematical equation

C t u L 4 2 + C ( n L 2 + 1 + ( p + q ) L 4 ) t u L 2 Mathematical equation

1 4 t u L 2 2 + C t u L 2 2 + C n L 2 2 + C + C ( p + q ) L 4 2 , Mathematical equation

which leads to

t u L ( 0 , T ; L 2 ) + t u L 2 ( 0 , T ; H 1 ) C . Mathematical equation(28)

And thus

u L ( 0 , T ; H 2 ) + u L 2 ( 0 , T ; H 3 ) C . Mathematical equation(29)

Applying tMathematical equation to (4), testing by tpMathematical equation, using (2), (10), (28), (29), (25) and (22), we have

     1 2 d d t ( t p ) 2 d x + | t p | 2 d x + n ( t p ) 2 d x Mathematical equation

    = - t u p t p d x - t n p t p d x Mathematical equation

= t u p t p d x + d i v ( u n + n S p + n S q - n ) p t p d x Mathematical equation

= t u p t p d x - ( u n + n S p + n S q - n ) ( p t p ) d x Mathematical equation

p L t u L 2 t p L 2 + C ( u L 4 n L 4 + C n L 4 ( p + q ) L 4 )      + n L 2 × ( p L t p L 2 + p L 4 t p L 4 ) Mathematical equation

C t p L 2 + C ( 1 + ( p + q ) L 4 + n L 2 )      ( t p L 2 + p L 4 t p L 4 ) Mathematical equation

1 8 t p L 2 2 + C + C ( p + q ) L 4 4 + C p L 4 4      + C n L 2 2 + C n L 2 2 t p L 2 2 ,       Mathematical equation

which gives

t p L ( 0 , T ; L 2 ) + t p L 2 ( 0 , T ; H 1 ) C , Mathematical equation(30)

and hence

p L ( 0 , T ; H 2 ) + p L 2 ( 0 , T ; H 3 ) C . Mathematical equation(31)

Similarly to (30)-(31), we have

t q L ( 0 , T ; L 2 ) + t q L 2 ( 0 , T ; H 1 ) C , Mathematical equation(32)

q L ( 0 , T ; H 2 ) + q L 2 ( 0 , T ; H 3 ) C . Mathematical equation(33)

Similarly to (26), we have

n L ( 0 , T ; L ) C . Mathematical equation(34)

Now testing (3) by tn-Δn,Mathematical equationit is easy to verify that

n L ( 0 , T ; H 1 ) + n L 2 ( 0 , T ; H 2 ) + t n L 2 ( 0 , T ; L 2 ) C , Mathematical equation(35)

we omit the details here.

Applying tMathematical equation to (3), testing by tnMathematical equation, using (2), (34), (35) and (28)-(33), we arrive at

1 2 d d t ( t n ) 2 d x + | t n | 2 d x Mathematical equation

= - t u n t n d x + t [ n S ( p + q ) ] t n d x Mathematical equation

= - t u n t n d x + [ t n S ( p + q ) + n ( S n t n +          S p t p + S q t q ) ( p + q ) + n S ( t p + t q ) ] t n d x Mathematical equation

t u L 2 n L t n L 2 + C ( ( t n , t p , t q ) L 4 ( p + q ) L 4 Mathematical equation

     + t p L 2 + t q L 2 ) t n L 2 Mathematical equation

C t n L 2 + C ( t n L 4 + t p H 1 + t q H 1 ) t n L 2 Mathematical equation

1 8 t n L 2 2 + C + C t n L 2 2 + C t p H 1 2 + C t q H 1 2 , Mathematical equation

which implies

t n L ( 0 , T ; L 2 ) + t n L 2 ( 0 , T ; H 1 ) C , Mathematical equation(36)

whence

n L ( 0 , T ; H 2 ) + n L 2 ( 0 , T ; H 3 ) C Mathematical equation(37)

This completes the proof.

References

  1. Kozono H, Miura M, Sugiyama Y. Existence and uniqueness theorem on mild solutions to the Keller-Segel system coupled with the Navier-Stokes fluid[J]. Journal of Functional Analysis, 2016, 270(5): 1663-1683. [Google Scholar]
  2. Kozono H, Miura M, Sugiyama Y. Time global existence and finite time blow-up criterion for solutions to the Keller-Segel system coupled with the Navier-Stokes fluid[J]. Journal of Differential Equations, 2019, 267(9): 5410-5492. [Google Scholar]
  3. Winkler M. Small-Mass solutions in the two-dimensional Keller-Segel system coupled to the Navier-Stokes equations[J]. SIAM Journal on Mathematical Analysis, 2020, 52(2): 2041-2080. [Google Scholar]
  4. Chen M C, Chen F Q, Lu S Q. A logarithmic extensibility criterion for a Keller-Segel-Navier-Stokes system in a bounded domain[J]. Journal of Mathematical Physics, Analysis, Geometry, 2025, 21(2): 179-202. [Google Scholar]
  5. Bellomo N, Bellouquid A, Tao Y, et al. Toward a mathematical theory of Keller-Segel models of pattern formation in biological tissues[J]. Mathematical Models and Methods in Applied Sciences, 2015, 25(9): 1663-1763. [Google Scholar]
  6. Kiselev A, Ryzhik L. Biomixing by chemotaxis and enhancement of biological reactions[J]. Communications in Partial Differential Equations, 2012, 37(2): 298-318. [Google Scholar]
  7. Wang Y L, Winkler M, Xiang Z Y. Global classical solutions in a two-dimensional chemotaxis-Navier-Stokes system with subcritical sensitivity[J]. Annali Scuola Normale Superiore - Classe Di Scienze, 2018, 18(5): 421-466. [Google Scholar]
  8. Fan J S, Li F C. Vanishing viscosity limits of a chemotaxis-Navier-Stokes model[J]. Acta Mathematicae Applicatae Sinica, English Series, 2025, 41(4): 1156-1166. [Google Scholar]
  9. Keller E F, Segel L A. Initiation of slime mold aggregation viewed as an instability[J]. Journal of Theoretical Biology, 1970, 26(3): 399-415. [Google Scholar]
  10. Keller E F, Segel L A. Model for chemotaxis[J]. Journal of Theoretical Biology, 1971, 30(2): 225-234. [Google Scholar]
  11. Keller E F, Segel L A. Traveling bands of chemotactic bacteria: A theoretical analysis[J]. Journal of Theoretical Biology, 1971, 30(2): 235-248. [Google Scholar]
  12. Biler P. Global solutions to some parabolic-elliptic systems of chemotaxis[J]. Advances in Applied Mathematics, 1999, 9(1): 347-359. [Google Scholar]
  13. Corrias L, Perthame B, Zaag H. Global solutions of some chemotaxis and angiogenesis systems in high space dimensions[J]. Milan Journal of Mathematics, 2004, 72(1): 1-28. [Google Scholar]
  14. Hillen T, Painter K J. A user's guide to PDE models for chemotaxis[J]. Journal of Mathematical Biology, 2009, 58(1): 183-217. [Google Scholar]
  15. Horstmann D. From 1970 until present: The Keller-Segel model in chemotaxis and its consequences: I[J]. Jahresbericht der Deutschen Mathematiker-Vereinigung, 2003, 105(3):103-165. [Google Scholar]
  16. Sleeman B D, Ward M J, Wei J C. The existence and stability of spike patterns in a chemotaxis model[J]. SIAM Journal on Applied Mathematics, 2005, 65(3): 790-817. [Google Scholar]
  17. Winkler M. Global solutions in a fully parabolic chemotaxis system with singular sensitivity[J]. Mathematical Methods in the Applied Sciences, 2011, 34(2): 176-190. [Google Scholar]
  18. Wrzosek D. Long-time behaviour of solutions to a chemotaxis model with volume-filling effect[J]. Proceedings of the Royal Society of Edinburgh: Section A Mathematics, 2006, 136(2): 431-444. [Google Scholar]
  19. Fan J S, Zhao K. Improved extensibility criteria and global well-posedness of a coupled chemotaxis-fluid model on bounded domains[J]. Discrete and Continuous Dynamical Systems - B, 2018, 23(9): 3949-3967. [Google Scholar]

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.