Open Access
| Issue |
Wuhan Univ. J. Nat. Sci.
Volume 31, Number 2, April 2026
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|---|---|---|
| Page(s) | 185 - 204 | |
| DOI | https://doi.org/10.1051/wujns/2026312185 | |
| Published online | 13 May 2026 | |
- Grani G, Lamartina L, Durante C, et al. Follicular thyroid cancer and Hürthle cell carcinoma: Challenges in diagnosis, treatment, and clinical management[J]. The Lancet Diabetes & Endocrinology, 2018, 6(6): 500-514. [Google Scholar]
- Lloyd R V, Osamura R Y, Klöppel G, et al. World Health Organization Classification of Tumours of Endocrine Organs[M]. Lyon: IARC Press, 2017. [Google Scholar]
- Baloch Z W, Asa S L, Barletta J A, et al. Overview of the 2022 WHO classification of thyroid neoplasms[J]. Endocrine Pathology, 2022, 33(1): 27-63. [Google Scholar]
- Haugen B R, Alexander E K, Bible K C, et al. 2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer[J]. Thyroid, 2016, 26(1): 1-133. [Google Scholar]
- Jalaly J B, Baloch Z W. Hürthle-cell neoplasms of the thyroid: An algorithmic approach to pathologic diagnosis in light of molecular advances[J]. Seminars in Diagnostic Pathology, 2020, 37(5): 234-242. [Google Scholar]
- Doerfler W R, Nikitski A V, Morariu E M, et al. Molecular alterations in Hürthle cell nodules and preoperative cancer risk[J]. Endocrine-Related Cancer, 2021, 28(5): 301-309. [Google Scholar]
- Ganly I, Makarov V, Deraje S, et al. Integrated genomic analysis of Hürthle cell cancer reveals oncogenic drivers, recurrent mitochondrial mutations, and unique chromosomal landscapes[J]. Cancer Cell, 2018, 34(2): 256-270.e5. [Google Scholar]
- Ganly I, Filho J R, Eng S, et al. Genomic dissection of Hurthle cell carcinoma reveals a unique class of thyroid malignancy[J]. The Journal of Clinical Endocrinology and Metabolism, 2013, 98(5): E962-E972. [Google Scholar]
- Gopal R K, Kübler K, Calvo S E, et al. Widespread chromosomal losses and mitochondrial DNA alterations as genetic drivers in Hürthle cell carcinoma[J]. Cancer Cell, 2018, 34(2): 242-255.e5. [Google Scholar]
- Schatz-Siemers N, Brandler C T, Oweity T, et al. Hürthle cell lesions on thyroid fine needle aspiration cytology: Molecular and histologic correlation[J]. Diagnostic Cytopathology, 2019, 47(10): 977-985. [Google Scholar]
- Wong K S, Angell T E, Barletta J A, et al. Hürthle cell lesions of the thyroid: Progress made and challenges remaining[J]. Cancer Cytopathology, 2021, 129(5): 347-362. [Google Scholar]
- Evangelisti C, de Biase D, Kurelac I, et al. A mutation screening of oncogenes, tumor suppressor gene TP53 and nuclear encoded mitochondrial complex I genes in oncocytic thyroid tumors[J]. BMC Cancer, 2015, 15: 157. [Google Scholar]
- Kasaian K, Chindris A M, Wiseman S M, et al. MEN1 mutations in Hürthle cell (oncocytic) thyroid carcinoma[J]. J Clin Endocrinol Metab, 2015, 100(4): E611-E615. [Google Scholar]
- Landa I, Ibrahimpasic T, Boucai L, et al. Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers[J]. J Clin Invest, 2016, 126(3): 1052-1066. [Google Scholar]
- Nikiforova M N, Wald A I, Roy S, et al. Targeted next-generation sequencing panel (ThyroSeq) for detection of mutations in thyroid cancer[J]. J Clin Endocrinol Metab, 2013, 98(11): E1852-E1860. [Google Scholar]
- Wei S Z, LiVolsi V A, Montone K T, et al. PTEN and TP53 mutations in oncocytic follicular carcinoma[J]. Endocrine Pathology, 2015, 26(4): 365-369. [Google Scholar]
- McFadden D G, Sadow P M. Genetics, diagnosis, and management of Hürthle cell thyroid neoplasms[J]. Frontiers in Endocrinology, 2021, 12: 696386. [Google Scholar]
- Yeh J J, Lunetta K L, van Orsouw N J, et al. Somatic mitochondrial DNA (mtDNA) mutations in papillary thyroid carcinomas and differential mtDNA sequence variants in cases with thyroid tumours[J]. Oncogene, 2000, 19(16): 2060-2066. [Google Scholar]
- Bonora E, Porcelli A M, Gasparre G, et al. Defective oxidative phosphorylation in thyroid oncocytic carcinoma is associated with pathogenic mitochondrial DNA mutations affecting complexes I and Ⅲ[J]. Cancer Research, 2006, 66(12): 6087-6096. [Google Scholar]
- Gasparre G, Porcelli A M, Bonora E, et al. Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors[J]. Proceedings of the National Academy of Sciences of the United States of America, 2007, 104(21): 9001-9006. [Google Scholar]
- Máximo V, Sobrinho-Simões M. Mitochondrial DNA 'common' deletion in Hürthle cell lesions of the thyroid[J]. The Journal of Pathology, 2000, 192(4): 561-562. [Google Scholar]
- Wredenberg A, Wibom R, Wilhelmsson H, et al. Increased mitochondrial mass in mitochondrial myopathy mice[J]. Proceedings of the National Academy of Sciences of the United States of America, 2002, 99(23): 15066-15071. [Google Scholar]
- Goffredo P, Roman S A, Sosa J A. Hurthle cell carcinoma: A population-level analysis of 3311 patients[J]. Cancer, 2013, 119(3): 504-511. [Google Scholar]
- Chindris A M, Casler J D, Bernet V J, et al. Clinical and molecular features of Hürthle cell carcinoma of the thyroid[J]. The Journal of Clinical Endocrinology and Metabolism, 2015, 100(1): 55-62. [Google Scholar]
- Shaha A R, Shah J P, Loree T R. Patterns of nodal and distant metastasis based on histologic varieties in differentiated carcinoma of the thyroid[J]. The American Journal of Surgery, 1996, 172(6): 692-694. [Google Scholar]
- Haigh P I, Urbach D R. The treatment and prognosis of Hürthle cell follicular thyroid carcinoma compared with its non-Hürthle cell counterpart[J]. Surgery, 2005, 138(6): 1152-1158. [Google Scholar]
- Kushchayeva Y, Duh Q Y, Kebebew E, et al. Comparison of clinical characteristics at diagnosis and during follow-up in 118 patients with Hürthle cell or follicular thyroid cancer[J]. The American Journal of Surgery, 2008, 195(4): 457-462. [Google Scholar]
- Hundahl S A, Fleming I D, Fremgen A M, et al. A national cancer data base report on 53 856 cases of thyroid carcinoma treated in the U.S., 1985-1995[J]. Cancer, 1998, 83(12): 2638-2648. [Google Scholar]
- Ahmadi S, Stang M, Jiang X, et al. Hürthle cell carcinoma: Current perspectives[J]. OncoTargets and Therapy, 2016, 9: 6873-6884. [Google Scholar]
- Yutan E, Clark O H. Hürthle cell carcinoma[J]. Current Treatment Options in Oncology, 2001, 2(4): 331-335. [Google Scholar]
- Oluic B, Paunovic I, Loncar Z, et al. Survival and prognostic factors for survival, cancer specific survival and disease free interval in 239 patients with Hürthle cell carcinoma: A single center experience[J]. BMC Cancer, 2017, 17(1): 371. [Google Scholar]
- Petric R, Gazic B, Besic N. Prognostic factors for disease-specific survival in 108 patients with Hürthle cell thyroid carcinoma: A single-institution experience[J]. BMC Cancer, 2014, 14: 777. [Google Scholar]
- Mills S C, Haq M, Smellie W J B, et al. Hürthle cell carcinoma of the thyroid: Retrospective review of 62 patients treated at the royal marsden hospital between 1946 and 2003[J]. European Journal of Surgical Oncology, 2009, 35(3): 230-234. [Google Scholar]
- Ucal Y, Ozpinar A. Proteomics in thyroid cancer and other thyroid-related diseases: A review of the literature[J]. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2020, 1868(11): 140510. [Google Scholar]
- Shao W G, Guo T N, Toussaint N C, et al. Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins[J]. Nature Communications, 2019, 10(1): 2524. [Google Scholar]
- Jiang L H, Wang M, Lin S, et al. A quantitative proteome map of the human body[J]. Cell, 2020, 183(1): 269-283.e19. [Google Scholar]
- Sun Y T, Selvarajan S, Zang Z L, et al. Artificial intelligence defines protein-based classification of thyroid nodules[J]. Cell Discovery, 2022, 8(1): 85. [Google Scholar]
- Chen T, Ma J, Liu Y, et al. iProX in 2021: Connecting proteomics data sharing with big data[J]. Nucleic Acids Research, 2022, 50(D1): D1522-D1527. [Google Scholar]
- Consortium T U. UniProt: The universal protein knowledgebase[J]. Nucleic Acids Research, 2017, 45(D1): D158-D169. [Google Scholar]
- Shen W T, Song Z G, Zhong X, et al. Sangerbox: A comprehensive, interaction-friendly clinical bioinformatics analysis platform[J]. iMeta, 2022, 1(3): e36. [Google Scholar]
- Sherman B T, Hao M, Qiu J, et al. DAVID: A web server for functional enrichment analysis and functional annotation of gene lists (2021 update)[J]. Nucleic Acids Research, 2022, 50(W1): W216-W221. [Google Scholar]
- Szklarczyk D, Kirsch R, Koutrouli M, et al. The STRING database in 2023: Protein-protein association networks and functional enrichment analyses for any sequenced genome of interest[J]. Nucleic Acids Research, 2023, 51(D1): D638-D646. [Google Scholar]
- Shannon P, Markiel A, Ozier O, et al. Cytoscape: A software environment for integrated models of biomolecular interaction networks[J]. Genome Research, 2003, 13(11): 2498-2504. [Google Scholar]
- Zhou G Y, Soufan O, Ewald J, et al. NetworkAnalyst 3.0: A visual analytics platform for comprehensive gene expression profiling and meta-analysis[J]. Nucleic Acids Research, 2019, 47(W1): W234-W241. [Google Scholar]
- Davis C A, Hitz B C, Sloan C A, et al. The encyclopedia of DNA elements (ENCODE): Data portal update[J]. Nucleic Acids Research, 2018, 46(D1): D794-D801. [Google Scholar]
- Liu Z P, Wu C L, Miao H Y, et al. RegNetwork: An integrated database of transcriptional and post-transcriptional regulatory networks in human and mouse[J]. Database, 2015, 2015: bav095. [Google Scholar]
- Piñero J, Bravo À, Queralt-Rosinach N, et al. DisGeNET: A comprehensive platform integrating information on human disease-associated genes and variants[J]. Nucleic Acids Research, 2017, 45(D1): D833-D839. [Google Scholar]
- Wishart D S, Feunang Y D, Guo A C, et al. DrugBank 5.0: A major update to the DrugBank database for 2018[J]. Nucleic Acids Research, 2018, 46(D1): D1074-D1082. [Google Scholar]
- Yang X M, Wang X Q, Hu L P, et al. Nucleolar HEAT repeat containing 1 up-regulated by the mechanistic target of rapamycin complex 1 signaling promotes hepatocellular carcinoma growth by dominating ribosome biogenesis and proteome homeostasis[J]. Gastroenterology, 2023, 165(3): 629-646. [Google Scholar]
- Penzo M, Montanaro L, Treré D, et al. The ribosome biogenesis-cancer connection[J]. Cells, 2019, 8(1): 55. [Google Scholar]
- Narla A, Ebert B L. Ribosomopathies: Human disorders of ribosome dysfunction[J]. Blood, 2010, 115(16): 3196-3205. [Google Scholar]
- Stelzer G, Rosen N, Plaschkes I, et al. The GeneCards suite: From gene data mining to disease genome sequence analyses[J]. Current Protocols in Bioinformatics, 2016, 54(1): 1.30.1-1.30.33. [Google Scholar]
- Máximo V, Botelho T, Capela J, et al. Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hürthle cell) tumours of the thyroid[J]. British Journal of Cancer, 2005, 92(10): 1892-1898. [Google Scholar]
- Chouhan S, Sawant M, Weimholt C, et al. TNK2/ACK1-mediated phosphorylation of ATP5F1A (ATP synthase F1 subunit alpha) selectively augments survival of prostate cancer while engendering mitochondrial vulnerability[J]. Autophagy, 2023, 19(3): 1000-1025. [Google Scholar]
- Sharma R K, Chafik A, Bertolin G. Aurora kinase A/AURKA functionally interacts with the mitochondrial ATP synthase to regulate energy metabolism and cell death[J]. Cell Death Discovery, 2023, 9(1): 203. [Google Scholar]
- Ba Y S, Ma F W, Ma Y W, et al. ATP5A1 participates in transcriptional and posttranscriptional regulation of cancer-associated genes by modulating their expression and alternative splicing profiles in HeLa cells[J]. Technology in Cancer Research & Treatment, 2021, 20: 15330338211039126. [Google Scholar]
- Yuan L S, Chen L, Qian K Y, et al. A novel correlation between ATP5A1 gene expression and progression of human clear cell renal cell carcinoma identified by co-expression analysis[J]. Oncology Reports, 2018, 39(2): 525-536. [Google Scholar]
- Repetto O, De Re V, Giuffrida P, et al. Proteomics signature of autoimmune atrophic gastritis: Towards a link with gastric cancer[J]. Gastric Cancer, 2021, 24(3): 666-679. [Google Scholar]
- Zhang G F, Zhong J M, Lin L, et al. Loss of ATP5A1 enhances proliferation and predicts poor prognosis of colon adenocarcinoma[J]. Pathology–Research and Practice, 2022, 230: 153679. [Google Scholar]
- Yue L Y, Liu P, Ma N T, et al. Interaction between extracellular ATP5A1 and LPS alleviates LPS-induced neuroinflammation in mice[J]. Neuroscience Letters, 2021, 758: 136005. [Google Scholar]
- Lines M A, Cuillerier A, Chakraborty P, et al. A recurrent de novo ATP5F1A substitution associated with neonatal complex V deficiency[J]. European Journal of Human Genetics, 2021, 29(11): 1719-1724. [Google Scholar]
- Nasca A, Mencacci N E, Invernizzi F, et al. Variants in ATP5F1B are associated with dominantly inherited dystonia[J]. Brain, 2023, 146(7): 2730-2738. [Google Scholar]
- Slater K, Bosch R, Smith K F, et al. 1, 4-dihydroxy quininib modulates the secretome of uveal melanoma tumour explants and a marker of oxidative phosphorylation in a metastatic xenograft model[J]. Frontiers in Medicine, 2023, 9: 1036322. [Google Scholar]
- Mahdevar M, Vatandoost J, Seyed Forootan F, et al. Steroid receptor RNA activator gene footprint in the progression and drug resistance of colorectal cancer through oxidative phosphorylation pathway[J]. Life Sciences, 2021, 285: 119950. [Google Scholar]
- Fiorillo M, Scatena C, Naccarato A G, et al. Bedaquiline, an FDA-approved drug, inhibits mitochondrial ATP production and metastasis in vivo, by targeting the gamma subunit (ATP5F1C) of the ATP synthase[J]. Cell Death and Differentiation, 2021, 28(9): 2797-2817. [Google Scholar]
- Song K H, Kim J H, Lee Y H, et al. Mitochondrial reprogramming via ATP5H loss promotes multimodal cancer therapy resistance[J]. The Journal of Clinical Investigation, 2018, 128(9): 4098-4114. [Google Scholar]
- Boada M, Antúnez C, Ramírez-Lorca R, et al. ATP5H/KCTD2 locus is associated with Alzheimer's disease risk[J]. Molecular Psychiatry, 2014, 19(6): 682-687. [Google Scholar]
- Zavileyskiy L, Bunik V. Regulation of p53 function by formation of non-nuclear heterologous protein complexes[J]. Biomolecules, 2022, 12(2): 327. [Google Scholar]
- Bottani E, Cerutti R, Harbour M E, et al. TTC19 plays a husbandry role on UQCRFS1 turnover in the biogenesis of mitochondrial respiratory complex Ⅲ[J]. Molecular Cell, 2017, 67(1): 96-105.e4. [Google Scholar]
- Yu J, Liang Q Y, Wang J, et al. Zinc-finger protein 331, a novel putative tumor suppressor, suppresses growth and invasiveness of gastric cancer[J]. Oncogene, 2013, 32(3): 307-317. [Google Scholar]
- Owens K M, Kulawiec M, Desouki M M, et al. Impaired OXPHOS complex Ⅲ in breast cancer[J]. PLoS One, 2011, 6(8): e23846. [Google Scholar]
- Natrajan R, MacKay A, Wilkerson P M, et al. Functional characterization of the 19q12 amplicon in grade Ⅲ breast cancers[J]. Breast Cancer Research, 2012, 14(2): R53. [Google Scholar]
- Becherini P, Caffa I, Piacente F, et al. SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice[J]. Cancer & Metabolism, 2021, 9(1): 6. [Google Scholar]
- Nordlund J, Milani L, Lundmark A, et al. DNA methylation analysis of bone marrow cells at diagnosis of acute lymphoblastic leukemia and at remission[J]. PLoS One, 2012, 7(4): e34513. [Google Scholar]
- Jun K H, Kim S Y, Yoon J H, et al. Amplification of the UQCRFS1 gene in gastric cancers[J]. Journal of Gastric Cancer, 2012, 12(2): 73-80. [Google Scholar]
- Ellinger J, Gromes A, Poss M, et al. Systematic expression analysis of the mitochondrial complex Ⅲ subunits identifies UQCRC1 as biomarker in clear cell renal cell carcinoma[J]. Oncotarget, 2016, 7(52): 86490-86499. [Google Scholar]
- De Marco C, Zoppoli P, Rinaldo N, et al. Genome-wide analysis of copy number alterations led to the characterisation of PDCD10 as oncogene in ovarian cancer[J]. Translational Oncology, 2021, 14(3): 101013. [Google Scholar]
- Ha J H, Jayaraman M, Yan M D, et al. GNAi2/gip2-regulated transcriptome and its therapeutic significance in ovarian cancer[J]. Biomolecules, 2021, 11(8): 1211. [Google Scholar]
- Sun Q R, Li J Q, Dong H, et al. UQCRFS1 serves as a prognostic biomarker and promotes the progression of ovarian cancer[J]. Scientific Reports, 2023, 13(1): 8335. [Google Scholar]
- Bai H Y, Wang Y L, Liu H M, et al. Development of a four-mRNA expression-based prognostic signature for cutaneous melanoma[J]. Frontiers in Genetics, 2021, 12: 680617. [Google Scholar]
- Yusenko M V, Ruppert T, Kovacs G. Analysis of differentially expressed mitochondrial proteins in chromophobe renal cell carcinomas and renal oncocytomas by 2-D gel electrophoresis[J]. International Journal of Biological Sciences, 2010, 6(3): 213-224. [Google Scholar]
- Liu J P, Zhan X Q, Li M Y, et al. Mitochondrial proteomics of nasopharyngeal carcinoma metastasis[J]. BMC Medical Genomics, 2012, 5: 62. [Google Scholar]
- Zeng J, Li G L, Xia Y, et al. miR-204/COX5A axis contributes to invasion and chemotherapy resistance in estrogen receptor-positive breast cancers[J]. Cancer Letters, 2020, 492: 185-196. [Google Scholar]
- Jung S E, Kim S W, Jeong S, et al. MicroRNA-26a/b-5p promotes myocardial infarction-induced cell death by downregulating cytochrome c oxidase 5a[J]. Experimental & Molecular Medicine, 2021, 53(9): 1332-1343. [Google Scholar]
- Stanke K M, Wilson C, Kidambi S. High expression of glycolytic genes in clinical glioblastoma patients correlates with lower survival[J]. Frontiers in Molecular Biosciences, 2021, 8: 752404. [Google Scholar]
- Majercikova Z, Dibdiakova K, Gala M, et al. Different approaches for the profiling of cancer pathway-related genes in glioblastoma cells[J]. International Journal of Molecular Sciences, 2022, 23(18): 10883. [Google Scholar]
- Ganly I, Liu E M, Kuo F S, et al. Mitonuclear genotype remodels the metabolic and microenvironmental landscape of Hürthle cell carcinoma[J]. Science Advances, 2022, 8(25): eabn9699. [Google Scholar]
- Comelli M, Metelli G, Mavelli I. Downmodulation of mitochondrial F0F1 ATP synthase by diazoxide in cardiac myoblasts: A dual effect of the drug[J]. American Journal of Physiology Heart and Circulatory Physiology, 2007, 292(2): H820-H829. [Google Scholar]
- Ravindra K C, Ho W E, Cheng C, et al. Untargeted proteomics and systems-based mechanistic investigation of artesunate in human bronchial epithelial cells[J]. Chemical Research in Toxicology, 2015, 28(10): 1903-1913. [Google Scholar]
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